2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

Base Information

Chemical Name:2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate
CAS No.:106544-61-0
Molecular Formula:C₂₄H₃₄NO₄Si*ClO₄
Molecular Weight:528.074
Hs Code.:

Synonyms:2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

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Chemical Property of 2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

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Technology Process of 2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

There total 5 articles about 2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3382-18-1
6,7-dimethoxy-3,4-dihydro-isoquinoline

: 106544-59-6
4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl bromide

: 106544-61-0
2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

Guidance literature:: With silver perchlorate; In acetonitrile; at 25 ℃; for 12h;
DOI:10.1021/jo00256a038

Reference yield:

: 53207-00-4
1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene

: 106544-61-0
2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / Mg / tetrahydrofuran

2: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 8 h

3: 98 percent / NaBH₄ / ethanol / 1 h / 25 °C

4: 70 percent / triphenylphosphine / diethyl ether / 0.5 h / 25 °C

5: 65 percent / AgClO₄ / acetonitrile / 12 h / 25 °C

With sodium tetrahydroborate; n-butyllithium; silver perchlorate; magnesium; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; acetonitrile;
DOI:10.1021/jo00256a038

Reference yield:

: 106544-58-5
(4,5-dimethoxy-2-(trimethylsilyl)benzyl)trimethylsilane

: 106544-61-0
2-(4,5-dimethoxy-2-((trimethylsilyl)methyl)benzyl)-6,7-dimethoxy-3,4-dihydroisoquinolinium perchlorate

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / Br₂ / CCl₄ / 0.5 h / 25 °C

2: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 8 h

3: 98 percent / NaBH₄ / ethanol / 1 h / 25 °C

4: 70 percent / triphenylphosphine / diethyl ether / 0.5 h / 25 °C

5: 65 percent / AgClO₄ / acetonitrile / 12 h / 25 °C

With sodium tetrahydroborate; n-butyllithium; bromine; silver perchlorate; triphenylphosphine; In tetrachloromethane; diethyl ether; ethanol; acetonitrile;
DOI:10.1021/jo00256a038