13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 84877-93-0
• Molecular Formula: C₃₅H₄₁Cl₃N₄O₈
• Molecular Weight: 752.092
• Mol file: 84877-93-0.mol

Synonyms:13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 8 articles about 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{4-Methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester + acetyl chloride (75-36-5) → 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester (84877-93-0)

Guidance literature:

With dmap; In dichloromethane; at 25 ℃;

DOI:10.1021/ja00344a071

Reference yield:

3-(4'-bromophenyl)-(Z)-propenoic acid methyl ester (84878-00-2) → 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester (84877-93-0)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / Heating

2: BF₃OEt, acetic acid / CH₂Cl₂ / 0 °C

3: chlorobenzene / 120 °C

4: BF₃OEt

With pyridine; acetic acid; In dichloromethane; chlorobenzene;

Reference yield:

(Z)-3-{4-[5-(1-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester (84878-01-3) → 13-Acetyl-2-{4-methoxy-3-[4-((Z)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-4-oxo-2,3,4,6,7,9,10,11,12,13,14,15-dodecahydro-5H-1,4a,8,13-tetraaza-benzocyclotridecene-8-carboxylic acid 2,2,2-trichloro-ethyl ester (84877-93-0)

Guidance literature:

Multi-step reaction with 4 steps

1: BF₃OEt, acetic acid / CH₂Cl₂ / 0 °C

2: chlorobenzene / 120 °C

3: BF₃OEt

With acetic acid; In dichloromethane; chlorobenzene;

upstream raw materials:

acetyl chloride

3-(4'-bromophenyl)-(Z)-propenoic acid methyl ester

(Z)-3-{4-[5-(1-Amino-2-methoxycarbonyl-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester

(Z)-3-{4-[5-(1-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-2-methoxy-phenoxy]-phenyl}-acrylic acid methyl ester