2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

Base Information

Chemical Name:2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride
CAS No.:84208-37-7
Molecular Formula:C₁₈H₁₆Cl₂N₄O₇S*ClH
Molecular Weight:539.781
Hs Code.:

Synonyms:2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

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Chemical Property of 2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

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Technology Process of 2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

There total 8 articles about 2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 84208-36-6
2-(2-chloroacetamido-4-thiazolyl)-(Z)-2-[1-methyl-1-(p-nitrobenzyloxycarbonyl)ethyloxyimino]acetic acid

: 84208-37-7
2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

Guidance literature:: With phosphorus pentachloride; In dichloromethane; at 0 - 5 ℃; for 0.5h;
DOI:10.1248/cpb.32.2646

Reference yield:

: 19749-93-0
2-chloroacetamido-4-thiazolyl acetic acid ethyl ester

: 84208-37-7
2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 62.5 percent / SeO₂ / dioxane; acetic acid / 4 h / 110 - 115 °C

2: 84 percent / 1 N NaOH / ethanol / 1 h / Ambient temperature

3: 82 percent / 1 N NaOH / H₂O; tetrahydrofuran / 12 h / Ambient temperature; pH 5.0

4: 95 percent / PCl₅ / CH₂Cl₂ / 0.5 h / 0 - 5 °C

With sodium hydroxide; selenium(IV) oxide; phosphorus pentachloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetic acid;
DOI:10.1248/cpb.32.2646

Reference yield:

: 619-73-8
4-nitrobenzyl chloride

: 84208-37-7
2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetyl chloride hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 29.6 g / pyridine / diethyl ether / 5 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

3: 90 percent / hydrazine hydrate / CH₂Cl₂ / 5 h / Ambient temperature

4: 82 percent / 1 N NaOH / H₂O; tetrahydrofuran / 12 h / Ambient temperature; pH 5.0

5: 95 percent / PCl₅ / CH₂Cl₂ / 0.5 h / 0 - 5 °C

With pyridine; sodium hydroxide; phosphorus pentachloride; potassium carbonate; hydrazine hydrate; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.2646