FMOC-ASU-OH

Base Information

• Chemical Name: FMOC-ASU-OH
• CAS No.: 218457-76-2
• Molecular Formula: C₂₃H₂₅NO₆
• Molecular Weight: 411.455
• Hs Code.: 2924299090
• Mol file: 218457-76-2.mol

Synonyms:N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-ALPHA-L-AMINOSUBERIC ACID;FMOC-ASU-OH;FMOC-L-2-AMINOSUBERIC ACID;FMOC-L-ALPHA-AMINOSUBERIC ACID;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)octanedioic acid

Chemical Property of FMOC-ASU-OH

Chemical Property:

• Boiling Point: 670.9±55.0 °C(Predicted)
• PKA: 3.89±0.21(Predicted)
• PSA: 112.93000
• Density: 1.286±0.06 g/cm3(Predicted)
• LogP: 4.40430
• Storage Temp.: Store at 0-5°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-L-alpha-aminosuberic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-ASU-OH

There total 1 articles about FMOC-ASU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S)-L-α-Aminosuberic acid (4254-88-0,19641-59-9) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → Fmoc-L-Asu-OH (218457-76-2,218457-78-4)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 20h;

DOI:10.1016/j.tetlet.2012.10.113

Reference yield: 6.0%

glycine allyl ester (59765-55-8) + Fmoc-L-Asu-OH (218457-76-2,218457-78-4) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + 1,2-diamino-benzene (95-54-5) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → C24H37N9O5 (1186489-64-4) + C28H42N10O4 (1186489-71-3)

Guidance literature:

1,2-diamino-benzene; With trityl chloride resin; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Fmoc-L-Asu-OH; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 9h;

glycine allyl ester; N-(fluoren-9-ylmethoxycarbonyl)glycine; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

DOI:10.1016/j.bmcl.2009.03.085

Reference yield:

Fmoc-L-Asu-OH (218457-76-2,218457-78-4) + 1,2-diamino-benzene (95-54-5) → C35H37N5O4 (1186489-69-9)

Guidance literature:

1,2-diamino-benzene; With trityl chloride resin; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Fmoc-L-Asu-OH; With 1-hydroxy-7-aza-benzotriazole; HATU;

DOI:10.1016/j.bmcl.2009.03.085

upstream raw materials:

(2S)-L-α-Aminosuberic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

C₂₄H₃₇N₉O₅

C₂₈H₄₂N₁₀O₄

C₃₅H₃₇N₅O₄

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