1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

Base Information

Chemical Name:1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine
CAS No.:1612164-62-1
Molecular Formula:C₂₀H₂₀N₆O
Molecular Weight:360.418
Hs Code.:

Synonyms:1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

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Chemical Property of 1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

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Technology Process of 1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

There total 5 articles about 1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 90832-58-9
2-(4-methoxyphenyl)pyrimidin-4-amine

: 1612172-44-7
6-chloro-1-isopropyl-1H-imidazo[4,5-c]pyridine

: 1612164-62-1
1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; In tert-butyl alcohol; at 120 ℃; for 12h; Inert atmosphere;

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1612164-62-1
1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / acetonitrile / 2 h / 110 °C / Inert atmosphere

2: sodium t-butanolate; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II) / tert-butyl alcohol / 12 h / 120 °C / Inert atmosphere

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; sodium t-butanolate; In acetonitrile; tert-butyl alcohol;

Reference yield:

: 1612171-75-1
(2-chloro-5-nitropyridin-4-yl)isopropylamine

: 1612164-62-1
1-isopropyl-N-(2-(4-methoxyphenyl)pyrimidin-4-yl)-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; Adam’s catalyst / ethyl acetate / 18 h / 20 °C

2: formic acid / 4 h / 80 °C

3: sodium t-butanolate; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II) / tert-butyl alcohol / 12 h / 120 °C / Inert atmosphere

With formic acid; Adam’s catalyst; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); hydrogen; sodium t-butanolate; In ethyl acetate; tert-butyl alcohol;