Technology Process of N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydro[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide
There total 6 articles about N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydro[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydroisoxazolo[3,4-d]pyrimidin-3-yl)acetic acid;
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
benzotriazol-1-ol;
In
1,2-dichloro-ethane;
at 20 ℃;
for 0.25h;
4-(4-bromophenyl)-1,3-thiazol-2-amine;
In
1,2-dichloro-ethane;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil / Reflux; Inert atmosphere
2.1: sulfuric acid / 1,4-dioxane / 1 h / Reflux
3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / 1,2-dichloro-ethane / 0.25 h / 20 °C
3.2: Inert atmosphere
With
dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
sulfuric acid; benzotriazol-1-ol;
In
1,4-dioxane; 1,2-dichloro-ethane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichlorophosphate / water / 3 h / Reflux
2.1: hydroxylamine hydrochloride; sodium acetate / isopropyl alcohol / 4 h / Reflux
3.1: pyridine / 6 h / Reflux; Inert atmosphere
4.1: sodium hydride / mineral oil / Reflux; Inert atmosphere
5.1: sulfuric acid / 1,4-dioxane / 1 h / Reflux
6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / 1,2-dichloro-ethane / 0.25 h / 20 °C
6.2: Inert atmosphere
With
dmap; hydroxylamine hydrochloride; sodium acetate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate;
sulfuric acid; benzotriazol-1-ol;
In
1,4-dioxane; pyridine; water; 1,2-dichloro-ethane; isopropyl alcohol; mineral oil;