65183-48-4

Upstream product

• 42963-41-7 6-hydroxyamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 108-24-7 acetic anhydride 
• 78-39-7 Triethyl orthoacetate 
• 65709-05-9 6-(ethylcarbamoyloxy-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione 
• 65183-54-2 3,5-dimethyl-7H-isoxazolo[3,4-d]pyrimidine-4,6-dione 
• 74-88-4 methyl iodide 
• 61541-41-1 6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 64-19-7 acetic acid 
• 32970-32-4 5-acetyl-6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 769-42-6 1,3-dimethylbarbituric acid 
• 123506-39-8 6-hydroxyamino-3-methyluracil 
• 506437-12-3 N-(1,3-dimethyl-6-uracilyl)-S,S-diphenylsulfilimine 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 506437-21-4 N-(5-acetyl-1,3-dimethyl-6-uracilyl)-S,S-diphenylsulfilimine 

Downstream Products

• 1335010-33-7 N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydro[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide 

Relevant academic research and scientific papers

AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS

Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).

Iodobenzene diacetate-promoted N-N and N-O bond formation for pyrazolo- and isoxazolopyrimidine syntheses

Pyrazolo[3,4-d]pyrimidine-4,6-dione derivatives were efficiently synthesized via the intramolecular N-N bond coupling of 5-iminomethyl-6-aminouracil derivatives using iodobenzene diacetate. The oxidative coupling was also applied to the analogous N-O bond

Ring closure reactions of β-nitroso-, β-acyl-, and β-thiocarbamoyl-α,β-unsaturated sulfilimines. Synthesis of [1,2,5]oxadiazolo[3,4-d]-, isoxazolo[3,4-d]-, and isothiazolo[3,4-d]pyrimidine derivatives from uracils

1,3-Dialkyl-6-chlorouracils were treated with S,S-diphenylsulfilimine to give N-(1,3-dialkyluracil-6-yl)-S,S-diphenylsulfilimines. The uracilylsulfilimines were nitrosated, acylated, or thiocarbamoylated to give N-(5-nitroso-, 5-acyl-, or 5-thiocarbamoyluracil-6-yl)sulfilimines, respectively. These conjugated sulfilimines were cyclized by thermolysis or photolysis to [1,2,5]oxadiazolo[3,4-d], isoxazolo[3,4-d], or isothiazolo[3,4-d]pyrimidine derivatives.

Ring closure reactions of azidouracils to oxazolo- and isoxazolopyrimidines [1]

Thermolysis of 6-azidouracils 1 in the presence of polyphosphoric acid leads either to oxazolo[5,4-d]pyrimidine-5,7-diones 5 (by reaction with benzoic acid 2a) or to isoxazolo[3,4-d]pyrimidine-4,6-diones 7 (by reaction with aliphatic carboxylic acids 2b,c

Pyrimidine Derivatives and Related Compounds. XLVI. Thermal and Photochemical Transformation of 5-Substituted 6-Azido-1,3-dimethyluracils into Fused Pyrimidines such as Isoxazolopyrimidines, Pyrazolo-pyrimidines, and Pyrimido-t

Thermolysis and photolysis of 6-azido-1,3-dimethyluracils possessing certain substituents (formyl, benzoyl, hydrazonomethyl, phenyl, and benzyl groups) at the 5-position provided new methods for the preparation of fused pyrimidines.Irradiation and heating