2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

Base Information

Chemical Name:2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester
CAS No.:120609-57-6
Molecular Formula:C₂₇H₄₄N₃O₉P
Molecular Weight:585.635
Hs Code.:

2-<hydroxy<1(R)-<N-<(benzyloxycarbonyl)-(3S,4S)-statyl-L-alanyl>amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

Synonyms:2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

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Chemical Property of 2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

Chemical Property:

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Technology Process of 2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

There total 5 articles about 2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 93287-37-7
(3S,4S)-4-(carbamic acid benzyl ester)-3-hydroxy-6-methyl-heptanoic acid

: 120636-91-1
{[(R)-1-((S)-2-Amino-propionylamino)-3-methyl-butyl]-hydroxy-phosphinoyl}-acetic acid methyl ester

: 120609-57-6
2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; a) 0 deg C, 1 h, b) r.t., 40 h;
DOI:10.1021/jm00127a041

Reference yield:

: 120609-67-8
methyl 2-phosphinyl>acetate

: 120609-57-6
2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 12 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

2: 100 percent / H₂ / 10 percent Pd/C / methanol; ethyl acetate / 827.4 Torr

3: 47 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00127a041

Reference yield:

: 120707-56-4
<1(R)-<(benzyloxycarbonyl)amino>-3-methylbutyl>phosphinic acid

: 120609-57-6
2-amino>-3-methylbutyl>phosphinyl>acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) trimethylsilyl chloride, triethylamine / 1.) THF, r.t., 2.) 2 h

2: 96 percent / H₂ / 5 percent Pd/C / methanol / 6 h / Ambient temperature

3: 12 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

4: 100 percent / H₂ / 10 percent Pd/C / methanol; ethyl acetate / 827.4 Torr

5: 47 percent / 1-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide / a) 0 deg C, 1 h, b) r.t., 40 h

With chloro-trimethyl-silane; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00127a041