(6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione

Base Information

• Chemical Name: (6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione
• CAS No.: 1366297-65-5
• Molecular Formula: C₃₈H₆₂N₂O₅SSi₃
• Molecular Weight: 743.243

Synonyms:(6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione

Chemical Property of (6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione

There total 1 articles about (6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-8-hydroxy-2-methyloctahydropyrrolo[1,2-a]piperazine-1,4-dione (1366297-64-4) + triethylsilyl trifluoromethyl sulfonate (79271-56-0) → (6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione (1366297-65-5)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2012.01.055

Reference yield: 50.0%

(6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione (1366297-65-5) + α,α-diphenylbenzenemethanesulfenyl chloride (35572-83-9) → (6R,8S,8aR)-6-([(tert-butyldiphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]-8a-([(triphenylmethyl)sulfanyl]disulfanyl)octahydropyrrolo[1,2-a]piperazine-1,4-dione (1366297-67-7)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2012.01.055

Reference yield: 30.0%

(6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione (1366297-65-5) + chloroformic acid ethyl ester (541-41-3) → ethyl (3R,6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-1,4-dioxo-8-[(triethylsilyl)oxy]octahydropyrrolo-[1,2-a]piperazine-3-carboxylate (1366297-69-9) + ethyl (3S,6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-2-methyl-1,4-dioxo-8-[(triethylsilyl)oxy]octahydropyrrolo-[1,2-a]piperazine-3-carboxylate (1366297-71-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -79 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2012.01.055

upstream raw materials:

(6R,8S,8aR)-8a-(([(tert-butyldimethylsilyl)oxy]methyl)sulfanyl)-6-([(tert-butyl-diphenylsilyl)oxy]methyl)-8-hydroxy-2-methyloctahydropyrrolo[1,2-a]piperazine-1,4-dione

triethylsilyl trifluoromethyl sulfonate

Downstream raw materials:

(3R,6R,8S,8aR)-3,8a-bis({[(tert-butyldimethylsilyl)oxy]methyl}sulfanyl)-6-{[(tert-butyldiphenylsilyl)oxy]methyl}-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione

(3S,6R,8S,8aR)-3,8a-bis({[(tert-butyldimethylsilyl)oxy]methyl}sulfanyl)-6-{[(tert-butyldiphenylsilyl)oxy]methyl}-2-methyl-8-[(triethylsilyl)oxy]octahydropyrrolo[1,2-a]piperazine-1,4-dione

ethyl (3R,6R,8S,8aR)-6-([(tert-butyldiphenylsilyl)oxy]methyl)-2-methyl-1,4-dioxo-8-[(triethylsilyl)oxy]-8a-([(triphenylmethyl)sulfanyl]disulfanyl)octahydropyrrolo[1,2-a]piperazine-3-carboxylate

(1R,2S,4R,7R)-4-([(tert-butyldiphenylsilyl)oxy]methyl)-2-hydroxy-11-methyl-8,9-dithia-5,11-diazatricyclo[5.2.2.0(1,5)]undecane-6,10-dione

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