4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

Base Information

Chemical Name:4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid
CAS No.:1621384-50-6
Molecular Formula:C₁₈H₁₉N₅O₄
Molecular Weight:369.38
Hs Code.:

Synonyms:4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

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Chemical Property of 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

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Technology Process of 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

There total 10 articles about 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1005196-67-7
methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

: 1621384-50-6
4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃;
DOI:10.1016/j.bmcl.2014.07.017

Reference yield:

: 40318-15-8
methyl 4-methyl-1H-pyrrole-3-carboxylate

: 1621384-50-6
4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 48 h / -40 - 20 °C / Inert atmosphere

2.1: sodium methylate / 1 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / Inert atmosphere; Green chemistry

3.2: 0.17 h / Inert atmosphere; Green chemistry

4.1: 160 °C

5.1: trichlorophosphate / 115 °C

6.1: N,N-dimethyl-formamide / 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 60 °C

With aluminum (III) chloride; water; sodium methylate; sodium hydride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.07.017

Reference yield:

: 2458-12-0
3-amino-p-toluic acid

: 1621384-50-6
4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 50 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0 - 25 °C

3.1: hydrogenchloride; water / 1,4-dioxane / 20 °C

4.1: N,N-dimethyl-formamide / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 60 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.07.017