2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

Base Information

Chemical Name:2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine
CAS No.:1234319-81-3
Molecular Formula:C₃₀H₂₉N₅O₉
Molecular Weight:603.588
Hs Code.:

Synonyms:2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

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Chemical Property of 2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

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Technology Process of 2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

There total 4 articles about 2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1360804-45-0
C₂₃H₂₃IN₄O₈

: 55-21-0,27208-38-4
benzamide

: 1234319-81-3
2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; toluene; at 0 ℃; for 36h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.012

Reference yield: 77.0%

: 1234319-76-6
6-benzyloxy-2-chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine

: 55-21-0,27208-38-4
benzamide

: 1234319-81-3
2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jo100808w

Reference yield:

: 16321-99-6
2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

: 1234319-81-3
2',3',5'-tri-O-acetyl-2-N-benzoyl-6-O-benzylguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; diiodomethane; iodine; isopentyl nitrite / tetrahydrofuran

2: sodium hydride / 20 °C

3: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; toluene / 36 h / 0 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; diiodomethane; iodine; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; toluene; 3: Buchwald-Hartwig amidation;
DOI:10.1016/j.tetlet.2012.01.012