3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone

Base Information

• Chemical Name: 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone
• CAS No.: 838851-05-1
• Molecular Formula: C₁₇H₂₅O₇P
• Molecular Weight: 372.355
• Mol file: 838851-05-1.mol

Synonyms:3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone

Chemical Property of 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone

There total 6 articles about 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate (838850-96-7) → 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone (838851-05-1)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; In methanol; at 20 ℃; for 20h;

DOI:10.1021/jm048970a

Reference yield:

ethyl 2-diethoxyphosphinoylacrylate (20345-61-3) → 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone (838851-05-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

1.2: tetrahydrofuran / 24 h / 20 °C

2.1: NaOMe / methanol / 0.5 h / 20 °C

2.2: H₂SO₄ / methanol / 2 h / -60 °C

3.1: NaBH₄; aq. NaOH / methanol / 20 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; sodium methylate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1021/jm048970a

Reference yield:

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-nitropentanoate (838850-85-4) → 3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone (838851-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOMe / methanol / 0.5 h / 20 °C

1.2: H₂SO₄ / methanol / 2 h / -60 °C

2.1: NaBH₄; aq. NaOH / methanol / 20 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; sodium methylate; In methanol;

DOI:10.1021/jm048970a

upstream raw materials:

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate

ethyl 2-diethoxyphosphinoylacrylate

1,2-dimethoxy-4-(2-nitroethyl)benzene

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-nitropentanoate