ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate

Base Information

• Chemical Name: ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate
• CAS No.: 838850-96-7
• Molecular Formula: C₁₉H₂₉O₈P
• Molecular Weight: 416.408
• Mol file: 838850-96-7.mol

Synonyms:ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate

Chemical Property of ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate

There total 4 articles about ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-nitropentanoate (838850-85-4) → ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate (838850-96-7)

Guidance literature:

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-nitropentanoate; With sodium methylate; In methanol; at 20 ℃; for 0.5h;

With sulfuric acid; In methanol; at -60 ℃; for 2h;

DOI:10.1055/s-2004-835656

Reference yield:

ethyl 2-diethoxyphosphinoylacrylate (20345-61-3) → ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate (838850-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

1.2: tetrahydrofuran / 24 h / 20 °C

2.1: NaOMe / methanol / 0.5 h / 20 °C

2.2: H₂SO₄ / methanol / 2 h / -60 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1021/jm048970a

Reference yield:

1,2-dimethoxy-4-(2-nitroethyl)benzene (70360-83-7) → ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-oxopentanoate (838850-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

1.2: tetrahydrofuran / 24 h / 20 °C

2.1: NaOMe / methanol / 0.5 h / 20 °C

2.2: H₂SO₄ / methanol / 2 h / -60 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.1021/jm048970a

upstream raw materials:

ethyl 2-diethoxyphosphoryl-5-(3,4-dimethoxyphenyl)-4-nitropentanoate

ethyl 2-diethoxyphosphinoylacrylate

1,2-dimethoxy-4-(2-nitroethyl)benzene

diethoxyphosphoryl-acetic acid ethyl ester

Downstream raw materials:

3-diethoxyphosphoryl-5-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-2(5H)-furanone