methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate

Base Information

• Chemical Name: methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate
• CAS No.: 1292307-18-6
• Molecular Formula: C₄₁H₄₆F₆N₄O₆S
• Molecular Weight: 836.896
• Mol file: 1292307-18-6.mol

Synonyms:methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate

Chemical Property of methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate

There total 6 articles about methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Bromo-2-bromomethyl-benzene (3433-80-5) → methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate (1292307-18-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / toluene / 3 h / Inert atmosphere; Reflux

1.2: pH 1

2.1: thionyl chloride / 15 h / 20 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; zinc(II) fluoride / N,N-dimethyl-formamide / 14 h / 90 °C / Sealed tube

4.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5 h / 0 - 75 °C

5.1: dichloromethane / 3 h / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With 4-methyl-morpholine; thionyl chloride; sodium hydride; potassium carbonate; HATU; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) fluoride; tri tert-butylphosphoniumtetrafluoroborate; In dichloromethane; Pionier 2076; N,N-dimethyl-formamide; toluene;

Reference yield:

3,3'-dimethylbutyrolactone (3709-08-8) → methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate (1292307-18-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / toluene / 3 h / Inert atmosphere; Reflux

1.2: pH 1

2.1: thionyl chloride / 15 h / 20 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; zinc(II) fluoride / N,N-dimethyl-formamide / 14 h / 90 °C / Sealed tube

4.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5 h / 0 - 75 °C

5.1: dichloromethane / 3 h / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With 4-methyl-morpholine; thionyl chloride; sodium hydride; potassium carbonate; HATU; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) fluoride; tri tert-butylphosphoniumtetrafluoroborate; In dichloromethane; Pionier 2076; N,N-dimethyl-formamide; toluene;

Reference yield:

C13H17BrO3 (1292306-59-2) → methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate (1292307-18-6)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 15 h / 20 °C

2: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; zinc(II) fluoride / N,N-dimethyl-formamide / 14 h / 90 °C / Sealed tube

3: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5 h / 0 - 75 °C

4: dichloromethane / 3 h / 20 °C

5: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With 4-methyl-morpholine; thionyl chloride; sodium hydride; potassium carbonate; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) fluoride; tri tert-butylphosphoniumtetrafluoroborate; In dichloromethane; Pionier 2076; N,N-dimethyl-formamide;

upstream raw materials:

1-Bromo-2-bromomethyl-benzene

3,3'-dimethylbutyrolactone

C₁₃H₁₇BrO₃

C₁₄H₁₉BrO₃

Downstream raw materials:

4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

Refernces