4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

Base Information

Chemical Name:4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid
CAS No.:1292305-33-9
Molecular Formula:C₄₀H₄₄F₆N₄O₆S
Molecular Weight:822.869
Hs Code.:

4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

Synonyms:4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

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Chemical Property of 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

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Technology Process of 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

There total 8 articles about 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1292307-18-6
methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate

: 1292305-33-9
4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

Guidance literature:: methyl 4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifIuoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 8h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate; pH=1;

Reference yield:

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 1292305-33-9
4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / toluene / 3 h / Inert atmosphere; Reflux

1.2: pH 1

2.1: thionyl chloride / 15 h / 20 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; zinc(II) fluoride / N,N-dimethyl-formamide / 14 h / 90 °C / Sealed tube

4.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5 h / 0 - 75 °C

5.1: dichloromethane / 3 h / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 8 h / 20 °C

7.2: pH 1

With 4-methyl-morpholine; thionyl chloride; water; sodium hydride; potassium carbonate; HATU; potassium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) fluoride; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; Pionier 2076; N,N-dimethyl-formamide; toluene;

Reference yield:

: 3709-08-8
3,3'-dimethylbutyrolactone

: 1292305-33-9
4-(2-(4-cyano-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)benzyloxy)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / toluene / 3 h / Inert atmosphere; Reflux

1.2: pH 1

2.1: thionyl chloride / 15 h / 20 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; zinc(II) fluoride / N,N-dimethyl-formamide / 14 h / 90 °C / Sealed tube

4.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 5 h / 0 - 75 °C

5.1: dichloromethane / 3 h / 20 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 8 h / 20 °C

7.2: pH 1

With 4-methyl-morpholine; thionyl chloride; water; sodium hydride; potassium carbonate; HATU; potassium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc(II) fluoride; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; Pionier 2076; N,N-dimethyl-formamide; toluene;