4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

Base Information

Chemical Name:4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine
CAS No.:1435937-00-0
Molecular Formula:C₁₅H₁₂F₃N₅
Molecular Weight:319.289
Hs Code.:

Synonyms:4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

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Technology Process of 4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

There total 3 articles about 4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3210-44-4
5,7-dimethyltetrazolo[1,5-a]pyrimidine

: 705-31-7
4-trifluoromethylphenylacetylene

: 1435937-00-0
4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 60 ℃; for 72h;
DOI:10.1002/ejoc.201201033

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1435937-00-0
4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: copper dichloride; sodium L-ascorbate / ethanol / 3 h / 20 °C

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 72 h / 60 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; copper dichloride; In ethanol; water; tert-butyl alcohol; 2: |Huisgen Cycloaddition;
DOI:10.1002/ejoc.201201033

Reference yield:

: 4472-44-0
2-chloro-4,6-dimethylpyrimidine

: 1435937-00-0
4,6-dimethyl-2-{4-[4-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 21 h / 100 °C

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 72 h / 60 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: |Huisgen Cycloaddition;
DOI:10.1002/ejoc.201201033