N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

Base Information

Chemical Name:N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline
CAS No.:685565-62-2
Molecular Formula:C₂₈H₃₅N₃O₄
Molecular Weight:477.604
Hs Code.:

Synonyms:N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

Suppliers and Price of N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

Chemical Property:

Purity/Quality:

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Technology Process of N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

There total 5 articles about N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 752202-08-7
4-[3-(1-piperidinyl)propyloxy]benzoyl chloride

: 685565-25-7
5-[(morpholin-4-yl)carbonyl]isoindoline trifluoroacetate

: 685565-62-2
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 685565-62-2
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / Heating / reflux

2: sodium carbonate; potassium iodide / butan-1-ol / 16 h / 105 °C

3: hydrogenchloride / water / 1 - 2 h / Heating / reflux

4: thionyl chloride / 1 h / Heating / reflux; Neat (no solvent)

5: triethylamine / dichloromethane

With hydrogenchloride; thionyl chloride; sodium carbonate; potassium carbonate; triethylamine; potassium iodide; In dichloromethane; water; acetone; butan-1-ol;

Reference yield:

: 685565-08-6
ethyl 4-(3-piperidin-1-ylpropoxy)benzoate

: 685565-62-2
N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 1 - 2 h / Heating / reflux

2: thionyl chloride / 1 h / Heating / reflux; Neat (no solvent)

3: triethylamine / dichloromethane

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane; water;