752202-08-7

Upstream product

• 75912-94-6 4-(3-chloropropoxy)benzoic acid ethyl ester 
• 685565-08-6 ethyl 4-(3-piperidin-1-ylpropoxy)benzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 69076-29-5 4-(3-chloropropoxy)benzoic acid methyl ester 
• 767286-87-3 4-(3-(piperidin-1-yl)propoxy)benzoic acid 
• 685565-09-7 4-(3-(piperidin-1-yl)propoxy)benzoic acid hydrochloride 

Downstream Products

• 685565-39-3 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]indoline 
• 685565-42-8 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]indole 
• 685565-57-5 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-7-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 685872-83-7 4-phenyl-9-[4-(3-piperidin-1-ylpropoxy)benzoyl]-1-oxa-4,9-diazaspiro-[5, 5]-undecan-3-one hydrochloride 
• 685872-81-5 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-(R,S)-2-phenylpyrrolidine hydrochloride 
• 1334335-21-5 C₁₇H₂₄N₂O₂ 
• 685565-58-6 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-4-fluoroisoindoline 
• 1116338-64-7 C₃₇H₄₅F₃N₄O₃S 
• 1116338-58-9 C₃₄H₄₀N₂O₂ 
• 685565-70-2 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]isoindoline 
• 685565-60-0 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-cyanoisoindoline 
• 685565-62-2 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(morpholin-4-yl)carbonyl]isoindoline 
• 685565-61-1 N-[4-(3-piperidin-1-ylpropoxy)benzoyl]-5-[(pyrrolidin-1-yl)carbonyl]isoindoline 

Relevant academic research and scientific papers

Novel and highly potent histamine H3 receptor ligands. Part 1: Withdrawing of hERG activity

Pre-clinical investigation of some aryl-piperidinyl ether histamine H3 receptor antagonists revealed a strong hERG binding. To overcome this issue, we have developed a QSAR model specially dedicated to H3 receptor ligands. This model was designed to be di

Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics

Histamine H3 receptor (H3R) antagonists have some antipsychotic properties although the clear molecular mechanism is still unknown. As actually the most effective and less side effective antipsychotics are drugs with multiple targets

ARYLOXYALKYLAMINE DERIVATES AS H3 RECEPTOR LIGANDS

The present invention relates to novel benzyloxy derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES

The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.