Technology Process of 2-ethynyl-1,4,5-trimethoxy-3-methylbenzene
There total 6 articles about 2-ethynyl-1,4,5-trimethoxy-3-methylbenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methyl-4-(3,4,6-trimethoxy-2-methylphenyl)but-3-yne-2-ol;
With
sodium hydroxide;
In
toluene;
for 6h;
Reflux;
With
hydrogenchloride;
In
water;
DOI:10.1039/c3ob42333f
- Guidance literature:
-
Multi-step reaction with 6 steps
1: trichlorophosphate / 24 h / 0 - 20 °C
2: dihydrogen peroxide; sulfuric acid / methanol; water / 0.33 h / 0 °C
3: potassium carbonate / N,N-dimethyl-formamide / 24 h / Inert atmosphere; Darkness
4: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 0.5 h / Inert atmosphere; Darkness
5: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / dimethyl sulfoxide / 24 h / 70 °C / Inert atmosphere; Sealed tube
6: sodium hydroxide / toluene / 6 h / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; sulfuric acid; dihydrogen peroxide; potassium carbonate; diethylamine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate;
In
methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
1: |Vilsmeier-Haack Formylation / 5: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob42333f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Inert atmosphere; Darkness
2: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 0.5 h / Inert atmosphere; Darkness
3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / dimethyl sulfoxide / 24 h / 70 °C / Inert atmosphere; Sealed tube
4: sodium hydroxide / toluene / 6 h / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; potassium carbonate; diethylamine; trifluoroacetic acid; sodium hydroxide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
3: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob42333f