53887-78-8Relevant articles and documents
A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system
Guo, Ying,Ji, Si-Zhe,Chen, Cheng,Liu, Hong-Wei,Zhao, Jian-Hong,Zheng, Yu-Lin,Ji, Ya-Fei
, p. 8651 - 8664 (2015/03/05)
A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.
Reaction of phenols with the 2,2-diphenyl-1-picrylhydrazyl radical. Kinetics and DFT calculations applied to determine ArO-H bond dissociation enthalpies and reaction mechanism
Foti, Mario C.,Daquino, Carmelo,Mackie, Iain D.,DiLabio, Gino A.,Ingold
experimental part, p. 9270 - 9282 (2009/04/07)
(Figure Presented) The formal H-atom abstraction by the 2,2-diphenyl-1-picrylhydrazyl (dpph?) radical from 27 phenols and two unsaturated hydrocarbons has been investigated by a combination of kinetic measurements in apolar solvents and density functional theory (DFT). The computed minimum energy structure of dpph? shows that the access to its divalent N is strongly hindered by an ortho H atom on each of the phenyl rings and by the o-NO2 groups of the picryl ring. Remarkably small Arrhenius pre-exponential factors for the phenols [range (1.3-19) × 105 M-1 s-1] are attributed to steric effects. Indeed, the entropy barrier accounts for up to ca. 70% of the free-energy barrier to reaction. Nevertheless, rate differences for different phenols are largely due to differences in the activation energy, Ea,1 (range 2 to 10 kcal/mol). In phenols, electronic effects of the substituents and intramolecular H-bonds have a large influence on the activation energies and on the ArO-H BDEs. There is a linear Evans-Polanyi relationship between E a,1 and the ArO-H BDEs: Ea,1/kcal x mol-1 = 0.918 BDE(ArO-H)/kcal x mol-1 - 70.273. The proportionality constant, 0.918, is large and implies a "late" or "product-like" transition state (TS), a conclusion that is congruent with the small deuterium kinetic isotope effects (range 1.3-3.3). This Evans-Polanyi relationship, though questionable on theoretical grounds, has profitably been used to estimate several ArO-H BDEs. Experimental ArO-H BDEs are generally in good agreement with the DFT calculations. Significant deviations between experimental and DFT calculated ArO-H BDEs were found, however, when an intramolecular H-bond to the O? center was present in the phenoxyl radical, e.g., in ortho semiquinone radicals. In these cases, the coupled cluster with single and double excitations correlated wave function technique with complete basis set extrapolation gave excellent results. The TSs for the reactions of dpph ? with phenol, 3- and 4-methoxyphenol, and 1,4-cyclohexadiene were also computed. Surprisingly, these TS structures for the phenols show that the reactions cannot be described as occurring exclusively by either a HAT or a PCET mechanism, while with 1,4-cyclohexadiene the PCET character in the reaction coordinate is much better defined and shows a strong π-π stacking interaction between the incipient cyclohexadienyl radical and a phenyl ring of the dpph? radical.
A Facile Method for Regiospecific Hydroxylation of Resorcinol Diethers
Srebnik, M.,Mechoulam, R.
, p. 1046 - 1048 (2007/10/02)
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