4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

Base Information

Chemical Name:4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran
CAS No.:1426250-62-5
Molecular Formula:C₂₈H₃₄N₂O₄
Molecular Weight:462.589
Hs Code.:

Synonyms:4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

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Chemical Property of 4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

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Technology Process of 4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

There total 4 articles about 4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1426250-63-6
4-tert-butyl-5-{4-[N-(4-ethoxycarbonylbutyl)benzimidazol-2-yl]-3-methoxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

: 1426250-62-5
4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: With sodium thiomethoxide; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 0.5h; Inert atmosphere;
DOI:10.3987/COM-12-12602

Reference yield:

: 5-(4-bromo-3-methoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

: 1426250-62-5
4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 48 h / 20 °C / Inert atmosphere

4.1: sodium thiomethoxide / N,N-dimethyl-formamide / 0.5 h / 20 - 140 °C / Inert atmosphere

With n-butyllithium; trifluoromethylsulfonic anhydride; sodium hydride; Triphenylphosphine oxide; sodium thiomethoxide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-12602

Reference yield:

: 244124-41-2
5-(4-carboxy-3-methoxyphenyl)-4-tert-butyl-3,3-dimethyl-2,3-dihydrofuran

: 1426250-62-5
4-tert-butyl-5-{4-[N-(4-carboxybutyl)benzimidazol-2-yl]-3-hydroxyphenyl}-3,3-dimethyl-2,3-dihydrofuran

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

3.1: sodium thiomethoxide / N,N-dimethyl-formamide / 0.5 h / 20 - 140 °C / Inert atmosphere

With trifluoromethylsulfonic anhydride; sodium hydride; Triphenylphosphine oxide; sodium thiomethoxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-12602