(S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Base Information

Chemical Name:(S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate
CAS No.:952507-76-5
Molecular Formula:C₃₃H₃₂F₃NO₅S
Molecular Weight:611.682
Hs Code.:

Synonyms:(S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Suppliers and Price of (S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

There total 3 articles about (S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 952507-72-1
(S)-N-benzyl-2,2,2-trifluoro-N-(3-hydroxy-4-(trityloxy)butyl)-acetamide

: 124-63-0
methanesulfonyl chloride

: 952507-76-5
(S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tet.2007.07.044

Reference yield:

: 952507-69-6
(S)-4-(benzylamino)-1-(trityloxy)butan-2-ol

: 952507-76-5
(S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / pyridine; potassium carbonate / tetrahydrofuran

2: 94 percent / diisopropylethylamine / CH₂Cl₂ / 0 °C

With pyridine; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2007.07.044

Reference yield:

: (S)-N-benzyl-3-hydroxy-4-(trityloxy)butanamide

: 952507-76-5
(S)-4-(N-benzyl-2,2,2-trifluoroacetamido)-1-(trityloxy)butan-2-yl-methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / lithium aluminum hydride / tetrahydrofuran / 48 h / 0 °C

2: 79 percent / pyridine; potassium carbonate / tetrahydrofuran

3: 94 percent / diisopropylethylamine / CH₂Cl₂ / 0 °C

With pyridine; lithium aluminium tetrahydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2007.07.044