3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591827-28-9
Molecular Formula:C₂₂H₂₀ClN₅O₄
Molecular Weight:453.885
Hs Code.:

Synonyms:3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 13 articles about 3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1591827-00-7
3-chloro-5-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591827-29-0
(6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydropyridazin-3-yl)methyl 4-methylbenzenesulfonate

: 1591827-28-9
3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 20h;

Reference yield:

: 1591827-27-8
6-(hydroxymethyl)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one

: 1591827-30-3
3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591827-31-4
(6-oxo-1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1,6-dihydropyridazin-3-yl)methyl-4-methylbenzenesulfonate

: 98-59-9
p-toluenesulfonyl chloride

: 1591827-28-9
3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 63001-30-9
methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate

: 1591827-28-9
3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate / tetrahydrofuran

2: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran

3: potassium carbonate; triethylamine / N,N-dimethyl-formamide; dichloromethane

With lithium borohydride; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;