3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

• Chemical Name: 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
• CAS No.: 1591827-30-3
• Molecular Formula: C₁₂H₈ClN₃O₂
• Molecular Weight: 261.667

Synonyms:3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Chemical Property of 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Chemical Property:

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Technology Process of 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 2 articles about 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(3-chloro-5-cyanophenoxy)-3-oxobutanoate (1591829-14-9) + formamidine acetic acid (3473-63-0) → 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile (1591827-30-3)

Guidance literature:

With AMINOHIPPURATE SODIUM; In methanol; water;

Reference yield:

3-chloro-5-hydroxybenzonitrile (473923-97-6) → 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile (1591827-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: AMINOHIPPURATE SODIUM / water; methanol

With AMINOHIPPURATE SODIUM; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

6-(hydroxymethyl)-2-(tetrahydro-2H-pyran-2-yl)pyridazin-3(2H)-one (1591827-27-8) + 3-chloro-5-((4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile (1591827-30-3) + (6-oxo-1-(tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1,6-dihydropyridazin-3-yl)methyl-4-methylbenzenesulfonate (1591827-31-4) + p-toluenesulfonyl chloride (98-59-9) → 3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile (1591827-28-9)

Guidance literature:

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-chloro-5-hydroxybenzonitrile

ethyl 2-(3-chloro-5-cyanophenoxy)-3-oxobutanoate

formamidine acetic acid

Downstream raw materials:

3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1-(tetrahydro-2H-pyran-2-yl)-1,6-dihydro pyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

3-chloro-5-((6-oxo-1-((6-oxo-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

3-chloro-5-((4-methyl-6-oxo-1-((6-oxo-1,6-dihydropyridazin-3-yl)methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

3-chloro-5-((1-((2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)methyl)-6-oxo-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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