(1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

Base Information

Chemical Name:(1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol
CAS No.:88056-99-9
Molecular Formula:C₁₈H₂₉NO
Molecular Weight:275.434
Hs Code.:

Synonyms:(1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

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Chemical Property of (1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

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Technology Process of (1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

There total 10 articles about (1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 917-64-6
methyl magnesium iodide

: (2S,3R,5S)-3-Methyl-2-phenyl-5-propyl-hexahydro-oxazolo[3,2-a]pyridine

: 88056-99-9
(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

: 88056-99-9
(1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

Guidance literature:: In diethyl ether; at -60 ℃; for 20h; Yields of byproduct given;
DOI:10.1021/ja00364a053

Reference yield: 87.0%

: 917-64-6
methyl magnesium iodide

: (2S,3R,5S)-3-Methyl-2-phenyl-5-propyl-hexahydro-oxazolo[3,2-a]pyridine

: 88056-99-9
(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

: 88056-99-9
(1S,2R)-2-((2S,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

Guidance literature:: In diethyl ether; at -60 ℃; for 20h; Yields of byproduct given;
DOI:10.1021/ja00364a053

Reference yield:

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 88056-99-9
(1S,2R)-2-((2R,6S)-2-Methyl-6-propyl-piperidin-1-yl)-1-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O / 1 h / pH 3.0

2: H₂O / 72 h / Ambient temperature; pH 3.0

3: 1.) LDA / 1.) THF, -78 deg C, 2.) 3 h

4: 1.) AgBF₄, 2.) Zn(NH₄)2 / 1.) THF, -60 deg C, 30 min

5: 87 percent / diethyl ether / 20 h / -60 °C

With silver tetrafluoroborate; Zn(NH₄)2; lithium diisopropyl amide; In diethyl ether; water;
DOI:10.1021/ja00364a053