5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

Base Information

Chemical Name:5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid
CAS No.:1621254-51-0
Molecular Formula:C₃₆H₃₁F₁₀NO₅
Molecular Weight:747.63
Hs Code.:

5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

Synonyms:5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

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Chemical Property of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

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Technology Process of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

There total 9 articles about 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.7%

: 1621254-44-1
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylate

: 1621254-51-0
5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 50 ℃;

Reference yield:

: 344-39-8
4-methoxy-1-nitro-2-(trifluoromethyl)benzene

: 1621254-51-0
5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-iodo-succinimide; sulfuric acid

2.1: copper; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide / 16 h / 80 °C

3.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.1: sodium cyanoborohydride / dichloromethane

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

6.1: hydrogen / methanol / 20 °C

7.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 1 h / 20 °C

7.2: 20 °C

8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

9.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-iodo-succinimide; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; copper; sodium cyanoborohydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 8.1: |Suzuki Coupling;

Reference yield:

: 1621256-17-4
C₈H₅F₃INO₃

: 1621254-51-0
5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2-fluoro-4'-methoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide / 16 h / 80 °C

2.1: acetic acid / dichloromethane / 0.5 h / 20 °C

3.1: sodium cyanoborohydride / dichloromethane

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

5.1: hydrogen / methanol / 20 °C

6.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 1 h / 20 °C

6.2: 20 °C

7.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; water; hydrogen; copper; sodium cyanoborohydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 7.1: |Suzuki Coupling;