1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

Base Information

Chemical Name:1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole
CAS No.:1433278-81-9
Molecular Formula:C₃₂H₂₈N₂S
Molecular Weight:472.654
Hs Code.:

Synonyms:1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

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Chemical Property of 1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

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Technology Process of 1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

There total 6 articles about 1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1-(4-cyanophenyl)-3-(4-methylphenyl)-2-phenyl-4-(2-thienyl)butane-1,4-dione

: 109-73-9,85404-21-3
N-butylamine

: 1433278-81-9
1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

Guidance literature:: With titanium(IV)isopropoxide; In toluene; at 100 ℃; for 18h; Inert atmosphere;
DOI:10.1002/chem.201204072

Reference yield:

: 17590-58-8
2-benzylidene-1,3-dithiane

: 1433278-81-9
1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / -20 - 25 °C / Inert atmosphere

2.1: copper(I) bromide; water / 24 h / 100 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; toluene / 3 h / 0 °C / Inert atmosphere

4.1: water; hydrogenchloride / acetonitrile / 3 h / 25 °C

4.2: 0.25 h

4.3: 1 h

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; toluene / 23 h / 0 - 25 °C / Inert atmosphere

6.1: titanium(IV)isopropoxide / toluene / 18 h / 100 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; titanium(IV)isopropoxide; 3-chloro-benzenecarboperoxoic acid; copper(I) bromide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 2.1: |Pummerer Sulfoxide Rearrangement / 3.1: |Fukuyama Coupling / 6.1: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1002/chem.201204072

Reference yield:

: 1433278-90-0
S-butyl 3-(1,3-dithian-2-ylidene)-3-phenyl-2-(4-methylphenyl)propanethioate

: 1433278-81-9
1-butyl-2-(4-cyanophenyl)-4-(4-methylphenyl)-3-phenyl-5-(2-thienyl)pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; toluene / 3 h / 0 °C / Inert atmosphere

2.1: water; hydrogenchloride / acetonitrile / 3 h / 25 °C

2.2: 0.25 h

2.3: 1 h

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; toluene / 23 h / 0 - 25 °C / Inert atmosphere

4.1: titanium(IV)isopropoxide / toluene / 18 h / 100 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; titanium(IV)isopropoxide; In tetrahydrofuran; toluene; acetonitrile; 1.1: |Fukuyama Coupling / 4.1: |Paal-Knorr Pyrrole Synthesis;
DOI:10.1002/chem.201204072