N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

Base Information

Chemical Name:N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide
CAS No.:69213-38-3
Molecular Formula:C₂₂H₂₃N₇O₂
Molecular Weight:417.47
Hs Code.:

Synonyms:N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

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Technology Process of N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

There total 4 articles about N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63365-14-0
2-amino-6-(1-piperidinyl)benzonitrile

: 66492-66-8
1-(4-Methoxybenzyl)-1H-tetrazole-5-carbonyl chloride

: 69213-38-3
N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

Guidance literature:: With pyridine; In dichloromethane; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm00138a021

Reference yield:

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 69213-38-3
N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / 6 h / 130 °C

2: KOH / ethanol

3: oxalyl chloride, pyridine / benzene / 0.5 h / 15 °C

4: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; potassium hydroxide; oxalyl dichloride; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00138a021

Reference yield:

: Chloro-[(Z)-4-methoxy-benzylimino]-acetic acid ethyl ester

: 69213-38-3
N-[2-cyano-3-(1-piperidinyl)phenyl]1-(4-methoxyphenylmethyl)-1H-tetrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazoic acid / CH₂Cl₂; benzene / 1.) RT, 1 h, 2.) reflux, 5 h

2: KOH / ethanol

3: oxalyl chloride, pyridine / benzene / 0.5 h / 15 °C

4: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; potassium hydroxide; hydrogen azide; oxalyl dichloride; In ethanol; dichloromethane; benzene;
DOI:10.1021/jm00138a021