4,5-Pyrimidinediamine, 2-methoxy

Base Information

• Chemical Name: 4,5-Pyrimidinediamine, 2-methoxy
• CAS No.: 104900-51-8
• Molecular Formula: C₅H₈N₄O
• Molecular Weight: 140.145
• Hs Code.: 2933599090
• Mol file: 104900-51-8.mol

Synonyms:2-Methoxy-4,5-diaminopyrimidine;2-Methoxypyrimidine-4,5-diamine;

Chemical Property of 4,5-Pyrimidinediamine, 2-methoxy

Chemical Property:

• Boiling Point: 367.847 °C at 760 mmHg
• Flash Point: 176.268 °C
• PSA: 87.05000
• Density: 1.342 g/cm³
• LogP: 0.81200
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxypyrimidine-4,5-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Pyrimidinediamine, 2-methoxy

There total 2 articles about 4,5-Pyrimidinediamine, 2-methoxy which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

2-methoxy-5-nitro-pyrimidin-4-ylamine (304646-29-5) → 2-methoxypyrimidine-4,5-diamine (104900-51-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h; under 775.743 Torr;

Reference yield:

C13H14N4O4 → 2-methoxypyrimidine-4,5-diamine (104900-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / water; acetonitrile / 12 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 775.74 Torr

With ammonium cerium (IV) nitrate; palladium 10% on activated carbon; hydrogen; In methanol; water; acetonitrile;

Reference yield:

2-methoxypyrimidine-4,5-diamine (104900-51-8) → C50H79N9O10S2

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / water; ethanol / 1 h / 130 °C / Microwave irradiation

2: dmap / N,N-dimethyl-formamide / 12 h / 40 °C

With dmap; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

2-methoxy-5-nitro-pyrimidin-4-ylamine

Refernces

• 1、 -. "Pteridinone derivatives for treating ocular hypertension". Page/Page column 5; 6. . Retrieved 2008/06/13.