4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester
• CAS No.: 1026628-21-6
• Molecular Formula: C₂₀H₁₅Cl₂N₃O₅
• Molecular Weight: 448.262

Synonyms:4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester

Chemical Property of 4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester

There total 2 articles about 4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dichloro-indole-2-carboxylic acid,ethyl ester (53995-82-7) → 4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester (1026628-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) phosporous oxychloride / 1.) 23 deg C, 15 min, 2.) 1,2-dichloroethane, 80 deg C, 6 h

2: acetonitrile; dioxane / 7 h / 70 °C

With trichlorophosphate; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jm960644a

Reference yield:

N-(4-Nitro-phenyl)-2-(triphenyl-λ5-phosphanylidene)-acetamide + ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate (153435-96-2) → 4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester (1026628-21-6)

Guidance literature:

In 1,4-dioxane; acetonitrile; at 70 ℃; for 7h;

DOI:10.1021/jm960644a

Reference yield: 100.0%

4,6-Dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylic acid ethyl ester (1026628-21-6) → Sodium; 4,6-dichloro-3-[(E)-2-(4-nitro-phenylcarbamoyl)-vinyl]-1H-indole-2-carboxylate

Guidance literature:

With sodium hydroxide; In isopropyl alcohol; at 60 ℃; for 11h;

DOI:10.1021/jm960644a

upstream raw materials:

ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate

4,6-dichloro-indole-2-carboxylic acid,ethyl ester

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