N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

Base Information

Chemical Name:N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine
CAS No.:1432294-05-7
Molecular Formula:C₂₂H₃₀ClN₉O₂
Molecular Weight:487.992
Hs Code.:

Synonyms:N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

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Chemical Property of N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

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Technology Process of N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

There total 6 articles about N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432292-33-5
C₂₇H₃₈ClN₉O₄

: 1432294-05-7
N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 775530-61-5
3,5-diamino-6-chloro-N-[(methylsulfanyl)methanimidoyl]pyrazine-2-carboxamide

: 1432296-28-0
[2-(4-aminomethyl-4-phenethyl-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 1432294-05-7
N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

Guidance literature:: In tetrahydrofuran; at 70 ℃;

Reference yield:

: 4878-36-8
3,5-diamino-6-chloro-pyrazine-2-carboxylic acid

: 1432294-05-7
N-[1-(2-amino-acetyl)-4-phenethyl-piperidin-4-ylmethyl]-N'-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluorormethanesulfonic acid / 1 h / Cooling with ice

1.2: 4 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / tert-butyl methyl ether; tetrahydrofuran / 20 °C

3.1: tetrahydrofuran / 70 °C

4.1: hydrogenchloride / methanol

With hydrogenchloride; trifluorormethanesulfonic acid; water; sodium hydroxide; In tetrahydrofuran; methanol; tert-butyl methyl ether;