(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

Base Information

Chemical Name:(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide
CAS No.:137252-33-6
Molecular Formula:C₃₀H₃₈F₃N₃O₄
Molecular Weight:561.645
Hs Code.:

(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

Synonyms:(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

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Chemical Property of (1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

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Technology Process of (1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

There total 10 articles about (1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 137143-96-5
(1R,2S)-2-[(S)-3-Phenyl-2-(2,2,2-trifluoro-acetylamino)-propionyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

: 137252-33-6
(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield:

: 59830-60-3
benzyl (1S)-(1-formyl-2-phenylethyl)carbamate

: 137252-33-6
(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 1) n-BuLi, N,N,N',N'-tetramethylethylenediamine, Ti(O-iPr)4 / 1) ether, -78 deg C, 0.5 h, 2a) -78 deg C, 0.5 h, 2b) to 0 deg C

2: 1) Hg(OAc)2, MeSO₃H, 2) meta-chloroperbenzoic acid, BF₃*Et₂O / 1) MeOH, 0 to 20 deg C, 15 h, 2) CH₂Cl₂

3: H₂ / 10percent Pd/C / propan-2-ol; tetrahydrofuran; H₂O / 16 h / 25 °C

4: Et₃N / CH₂Cl₂

5: 1) Me₃Al / 1) CH₃-CCl₃, 60 to 20 deg C, 1 h, 2) CH₃-CCl₃, 60 deg C, 4 h

6: 71 percent / K₂Cr₂O₇, Bu₄NHSO₄, 30percent H₂SO₄ / CH₂Cl₂ / 0.33 h / 25 °C

7: 69 percent / LiBH₄ / tetrahydrofuran / 2 h / -78 °C

With titanium(IV) isopropylate; potassium dichromate; lithium borohydride; n-butyllithium; methanesulfonic acid; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; boron trifluoride diethyl etherate; mercury(II) diacetate; hydrogen; trimethylaluminum; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 87143-44-0
1-cyclopentenylmethyl N,N-diisopropylcarbamate

: 137252-33-6
(1R,2S)-2-[(1R,2S)-1-Hydroxy-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-propyl]-cyclopentanecarboxylic acid ((1S,2S)-1-benzylcarbamoyl-2-methyl-butyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 1) n-BuLi, N,N,N',N'-tetramethylethylenediamine, Ti(O-iPr)4 / 1) ether, -78 deg C, 0.5 h, 2a) -78 deg C, 0.5 h, 2b) to 0 deg C

2: 1) Hg(OAc)2, MeSO₃H, 2) meta-chloroperbenzoic acid, BF₃*Et₂O / 1) MeOH, 0 to 20 deg C, 15 h, 2) CH₂Cl₂

3: H₂ / 10percent Pd/C / propan-2-ol; tetrahydrofuran; H₂O / 16 h / 25 °C

4: Et₃N / CH₂Cl₂

5: 1) Me₃Al / 1) CH₃-CCl₃, 60 to 20 deg C, 1 h, 2) CH₃-CCl₃, 60 deg C, 4 h

6: 71 percent / K₂Cr₂O₇, Bu₄NHSO₄, 30percent H₂SO₄ / CH₂Cl₂ / 0.33 h / 25 °C

7: 69 percent / LiBH₄ / tetrahydrofuran / 2 h / -78 °C

With titanium(IV) isopropylate; potassium dichromate; lithium borohydride; n-butyllithium; methanesulfonic acid; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; boron trifluoride diethyl etherate; mercury(II) diacetate; hydrogen; trimethylaluminum; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol;