2,4-difluoro-N,N-dimethylaniline

Base Information

Chemical Name:2,4-difluoro-N,N-dimethylaniline
CAS No.:78409-21-9
Molecular Formula:C₈H₉F₂N
Molecular Weight:157.163
Hs Code.:2921420090
DSSTox Substance ID:DTXSID50443322
Mol file:78409-21-9.mol

Synonyms:2,4-difluoro-N,N-dimethylaniline;78409-21-9;SCHEMBL5716211;DTXSID50443322;MFCD04116330;SB76315;2,4-bis(fluoranyl)-N,N-dimethyl-aniline;A839411

Suppliers and Price of 2,4-difluoro-N,N-dimethylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2,4-Difluoro-N,N-dimethylaniline 95+%
5g
$ 392.00

American Custom Chemicals Corporation
2,4-DIFLUORO-N,N-DIMETHYLANILINE 98.00%
50G
$ 3349.50

Alichem
2,4-Difluoro-N,N-dimethylaniline
5g
$ 329.60

Total 15 raw suppliers

Chemical Property of 2,4-difluoro-N,N-dimethylaniline

Chemical Property:

PSA：3.24000
LogP:2.03080
Storage Temp.:2-8°C
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:157.07030562
Heavy Atom Count:11
Complexity:127

Purity/Quality:

97% ^*data from raw suppliers

2,4-Difluoro-N,N-dimethylaniline 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=C(C=C(C=C1)F)F

Technology Process of 2,4-difluoro-N,N-dimethylaniline

There total 1 articles about 2,4-difluoro-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 512-56-1
trimethyl phosphite

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 78409-21-9
1-(dimethylamino)-2,4-difluorobenzene

Guidance literature:: With sodium hydroxide; Yield given. Multistep reaction; 180 deg C, 2 h, 2.) H₂O, reflux, 1 h;
DOI:10.1021/jm950639r

Reference yield:

: 78409-21-9
1-(dimethylamino)-2,4-difluorobenzene

: 181305-21-5
1-(5-Chloro-pyridin-2-yl)-3-[2-(3-dimethylamino-2,6-difluoro-phenyl)-ethyl]-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi / 1.) hexane, THF, -65 deg C, 0.5 h, 2.) hexane, THF, from -65 deg C to RT

2: 1.) NaOH, 2.) 4N aq. HCl / 1.) H₂O, methanol, -3 deg C, 15 min

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: acetonitrile / Ambient temperature

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm950639r

Reference yield:

: 78409-21-9
1-(dimethylamino)-2,4-difluorobenzene

: 181305-22-6
1-(5-Bromo-pyridin-2-yl)-3-[2-(3-dimethylamino-2,6-difluoro-phenyl)-ethyl]-thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi / 1.) hexane, THF, -65 deg C, 0.5 h, 2.) hexane, THF, from -65 deg C to RT

2: 1.) NaOH, 2.) 4N aq. HCl / 1.) H₂O, methanol, -3 deg C, 15 min

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: 80 - 100 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jm950639r