3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Base Information

Chemical Name:3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS No.:1336960-88-3
Molecular Formula:C₄₄H₄₅F₃N₄O
Molecular Weight:702.863
Hs Code.:

Synonyms:3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Chemical Property of 3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Technology Process of 3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

There total 7 articles about 3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1336960-23-6
3-(1,4'-bipiperidin-1'-ylmethyl)-8-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

: 16419-60-6
2-Methylphenylboronic acid

: 1336960-88-3
3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 150 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 20780-74-9
7-bromoisatin

: 1336960-88-3
3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 18 h / Reflux

1.3: pH 4 - 5

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 72 h / Reflux

3.1: dichloromethane / 2 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / dichloromethane / 20 °C

5.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; water; 5.1: Suzuki Coupling;

Reference yield:

: 101080-38-0,1191245-18-7
N-(2-bromophenyl)-2-isonitrosoacetanilide

: 1336960-88-3
3-(1,4'-bipiperidin-1'-ylmethyl)-8-(2-methylphenyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 0.75 h / 65 - 80 °C

1.2: 60 °C

2.1: potassium hydroxide / ethanol; water / 0.25 h

2.2: 18 h / Reflux

2.3: pH 4 - 5

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 72 h / Reflux

4.1: dichloromethane / 2 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / dichloromethane / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; sulfuric acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; water; 6.1: Suzuki Coupling;