(R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

Base Information

Chemical Name:(R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide
CAS No.:1394346-15-6
Molecular Formula:C₂₁H₁₉Cl₂F₂N₂O₂P
Molecular Weight:471.271
Hs Code.:

Synonyms:(R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

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Chemical Property of (R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

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Technology Process of (R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

There total 8 articles about (R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-(4-(5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-6-nitropyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

: 1394346-15-6
(R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

Guidance literature:: With hydrogenchloride; iron; In ethanol; Reflux; Large scale;
DOI:10.1021/acs.oprd.6b00402

Reference yield:

: 1029439-02-8
3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol

: 1394346-15-6
(R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / 1,2-dimethoxyethane; methanol; water / 5 h / Reflux; Large scale

2: pyridine / dichloromethane / 25 - 30 °C / Large scale

3: triethylamine / acetonitrile / Reflux

4: hydrogenchloride; iron / ethanol / Reflux; Large scale

With pyridine; hydrogenchloride; iron; sodium carbonate; triethylamine; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1021/acs.oprd.6b00402

Reference yield:

: (R)-4-(5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-6-nitropyridin-3-yl)-3-fluorophenol

: 1394346-15-6
(R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 25 - 30 °C / Large scale

2: triethylamine / acetonitrile / Reflux

3: hydrogenchloride; iron / ethanol / Reflux; Large scale

With pyridine; hydrogenchloride; iron; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.oprd.6b00402