(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

Base Information

Chemical Name:(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one
CAS No.:222307-14-4
Molecular Formula:C₁₉H₃₇NO₄Si
Molecular Weight:371.593
Hs Code.:

Synonyms:(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

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Chemical Property of (S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

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Technology Process of (S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

There total 1 articles about (S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 222307-14-4
(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / imidazole / dimethylformamide

2: 85 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂

With 1H-imidazole; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 222307-14-4
(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

: 1,3-dibenzyl-5-hydroxymethyl-2,6-dioxo-8-triisopropylsilanyloxymethyl-2,3,4,5,5a,6,8,8a-octahydro-1H-imidazo[4,5-e]isoindole-7-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 °C

1.3: 59 percent / H₂O₂ / ethyl acetate / 0 °C

2.1: 28 percent / o-xylene / 24 h / 140 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; o-xylene; 2.1: Diels-Alder reaction;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 34837-55-3
Phenylselenyl bromide

: 222307-14-4
(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-pyrrolidin-2-one

: 222307-20-2
(S)-(+)-N-tert-butyloxycarbonyl-5-(triisopropylsilyloxymethyl)-3-phenylselenyl-pyrrolidin-2-one

Guidance literature:: With lithium hexamethyldisilazane; Yield given; Multistep reaction; 1.) THF, 1 h, 2.) THF, overnight;
DOI:10.1016/S0040-4020(98)01094-1