(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

Base Information

Chemical Name:(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride
CAS No.:1401075-95-3
Molecular Formula:C₂₉H₂₇F₃N₂O*ClH
Molecular Weight:513.002
Hs Code.:

Synonyms:(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

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Chemical Property of (1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

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Technology Process of (1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

There total 5 articles about (1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401161-61-2
(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine

: 1401075-95-3
(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; hexane; ethyl acetate; for 0.166667h;

Reference yield:

: 106660-11-1
(3'-oxo-3',4'-dihydro-2'H-1',4'-benzoxazin-2'-yl)acetic acid

: 1401075-95-3
(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C / Cooling with ice

2.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 0 - 70 °C

2.2: 0.67 h / 0 - 50 °C

2.3: 0 °C / pH 10

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate; hexane; diethyl ether / 0.17 h

With hydrogenchloride; dimethylsulfide borane complex; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 95-55-6
2-amino-phenol

: 1401075-95-3
(1R)-1-(naphthalen-1-yl)-N-(2-(4-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)ethyl)ethanamine monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 3 h / 20 °C

2.1: triethylamine / 1,4-dioxane / 12 h / 20 °C / Reflux

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C / Cooling with ice

4.1: dimethylsulfide borane complex / tetrahydrofuran / 12 h / 0 - 70 °C

4.2: 0.67 h / 0 - 50 °C

4.3: 0 °C / pH 10

5.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate; hexane; diethyl ether / 0.17 h

With hydrogenchloride; dimethylsulfide borane complex; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; ethyl acetate; toluene;