(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

Base Information

Chemical Name:(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid
CAS No.:1117706-64-5
Molecular Formula:C₁₁H₉ClF₃NO₃
Molecular Weight:295.646
Hs Code.:

Synonyms:(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

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Chemical Property of (Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

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Technology Process of (Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

There total 1 articles about (Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 6290-49-9
methyl methoxyacetate

: 95656-51-2
4-amino-3-chloro-5-trifluoromethylbenzaldehyde

: 1117706-64-5
(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

Guidance literature:: methyl methoxyacetate; 4-amino-3-chloro-5-trifluoromethylbenzaldehyde; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 24h;

With sodium hydroxide; In tetrahydrofuran; at 30 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 97.0%

: 1117706-64-5
(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

: 1117706-66-7
(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-acrylic acid

Guidance literature:: With hydrogen bromide; In water; acetic acid; at 80 ℃; for 1.5h;

Reference yield:

: 1117706-64-5
(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid

: 868383-85-1
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / water; acetic acid / 1.5 h / 80 °C

2: chlorobis(2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane / n-heptane; acetic acid butyl ester / 10 - 20 °C

With hydrogen bromide; chlorobis(2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane; In n-heptane; acetic acid butyl ester; water; acetic acid;