(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

Base Information

Chemical Name:(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid
CAS No.:868383-85-1
Molecular Formula:C₁₀H₉ClF₃NO₃
Molecular Weight:283.635
Hs Code.:

Synonyms:(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

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Chemical Property of (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

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Technology Process of (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

There total 6 articles about (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1117706-66-7
(Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-acrylic acid

: 868383-85-1
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

Guidance literature:: With chlorobis(2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)borane; In n-heptane; acetic acid butyl ester; at 10 - 20 ℃;

Reference yield: 58.0%

: 868383-84-0
(E)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-acrylic acid

: 868383-85-1
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

Guidance literature:: (E)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-acrylic acid; With (-)-DIP chloride; triethylamine; In tetrahydrofuran; at -20 ℃; for 1.5h;

With sodium hydroxide; In tert-butyl methyl ether; water;

Reference yield:

: 926904-30-5
3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-oxo-propionic acid

: 868383-85-1
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

Guidance literature:: 3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-oxo-propionic acid; With triethylamine; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at -30 ℃; for 1.5h;

With sodium hydroxide; In tetrahydrofuran; tert-butyl methyl ether; water; at 0 - 20 ℃; for 0.416667h;