(1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate
CAS No.:1401625-43-1
Molecular Formula:C₂₀H₂₇BrN₂O₅
Molecular Weight:455.349
Hs Code.:

Synonyms:(1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

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Chemical Property of (1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

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Technology Process of (1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

There total 2 articles about (1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl-1-amino-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 34306-42-8
Boc-Abu

: 1401625-43-1
(1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

: 1401625-44-2
(1S,2S)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

Guidance literature:: With DMT-MM; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: methyl-1-amino-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1401625-43-1
(1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O,O'-dibenzoyl-L-tartaric acid / ethyl acetate; methanol / 2 h

1.2: 0.5 h

2.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

With 4-methyl-morpholine; chloroformic acid ethyl ester; O,O'-dibenzoyl-L-tartaric acid; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 1401625-43-1
(1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate

: 1401625-45-3
C₁₉H₂₅BrN₂O₅

Guidance literature:: (1R,2R)-methyl 2-(4-bromophenyl)-1-((S)-2-(tert-butoxycarbonylamino)butanamido)cyclopropanecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

With potassium hydrogensulfate; In tetrahydrofuran; water; pH=4;