tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate
CAS No.:1401625-46-4
Molecular Formula:C₁₉H₂₆BrN₃O₄
Molecular Weight:440.337
Hs Code.:

Synonyms:tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

There total 5 articles about tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401625-45-3
C₁₉H₂₅BrN₂O₅

: 1401625-46-4
tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: C₁₉H₂₅BrN₂O₅; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 1h;

With ammonia; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield:

: methyl-1-amino-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1401625-46-4
tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMT-MM / dichloromethane / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

With lithium hydroxide monohydrate; DMT-MM; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1161813-60-0
(1R,2R)-methyl 1-amino-2-(4-bromophenyl)cyclopropanecarboxylate

: 1401625-46-4
tert-butyl (S)-1-((1R,2R)-2-(4-bromophenyl)-1-carbamoylcyclopropylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;