N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Base Information

Chemical Name:N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
CAS No.:157327-99-6
Molecular Formula:C₃₅H₃₇N₅O₇
Molecular Weight:639.708
Hs Code.:

Synonyms:N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Suppliers and Price of N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Chemical Property:

Purity/Quality:: 99.3% ^*data from raw suppliers

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Technology Process of N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

There total 5 articles about N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 157025-66-6
N-[9-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

: 157327-99-6
N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1081/NCN-100107190

Reference yield: 74.0%

: N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

: 157327-99-6
N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 3608-58-0
3'-deoxyguanosine

: 157327-99-6
N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMS-Cl / pyridine / 0.33 h / 20 °C

1.2: 76 percent / pyridine / 2 h / 20 °C

2.1: 82 percent / pyridine / 20 °C

With pyridine; chloro-trimethyl-silane; In pyridine;
DOI:10.1081/NCN-100107190