N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu

Base Information

Chemical Name:N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu
CAS No.:81279-39-2
Molecular Formula:C41H51N5O8Si
Molecular Weight:769.97
Hs Code.:
Mol file:81279-39-2.mol

Synonyms:N2-Isobutyryl-2-O-(tert-butyldimethylsilyl)-5-O-(4,4-dimethoxytrityl)-gu;5-O-DMT-2-O-iBu-N-Bz-Guanosine;5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-O-[(tert-butyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine;5-DMT-2-TBDMS-iBu-rG;N-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-3-((tert-butyldiMethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyraMide;5-O-[bis(4-Methoxyphenyl)phenylMethyl]-2-O-[(1,1-diMethylethyl)diMethylsilyl]-N-(2-Methyl-1-oxopropyl)-Guanosine

Suppliers and Price of N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5''-O-DMT-2''-O-iBu-N-Bz-Guanosine
100mg
$ 45.00

Crysdot
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine 95+%
10g
$ 485.00

Crysdot
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine 95+%
5g
$ 317.00

Chemenu
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 95%
1g
$ 102.00

Chemenu
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 95%
5g
$ 299.00

Chemenu
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 95%
10g
$ 458.00

Biosynth Carbosynth
2'-O-(tert-Butyldimethylsilyl)-5'-O-DMT-N2-isobutyryl-guanosine
5 g
$ 320.00

Biosynth Carbosynth
2'-O-(tert-Butyldimethylsilyl)-5'-O-DMT-N2-isobutyryl-guanosine
500 mg
$ 65.00

Biosynth Carbosynth
2'-O-(tert-Butyldimethylsilyl)-5'-O-DMT-N2-isobutyryl-guanosine
2 g
$ 160.00

Biosynth Carbosynth
2'-O-(tert-Butyldimethylsilyl)-5'-O-DMT-N2-isobutyryl-guanosine
1 g
$ 100.00

Total 30 raw suppliers

Chemical Property of N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu

Chemical Property:

PKA:9.16±0.20(Predicted)
PSA：159.31000
Density:1.25
LogP:6.87400
Storage Temp.:2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

5''-O-DMT-2''-O-iBu-N-Bz-Guanosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5''-O-DMT-2''-O-iBu-N-Bz-Guanosine (cas# 81279-39-2) is a nucleotide used in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides to improve metabolic stability and elicit efficient RNAi-mediated gene silencing.

Technology Process of N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu

There total 9 articles about N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 182007-86-9
N²-isobutyryl-2'-O-tertbutyldimethylsilyl guanosine

: 81279-39-2
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1081/NCN-120022724

Reference yield: 74.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 81246-83-5
9-(5-O-dimethoxytrityl-β-D-ribofuranosyl)-2-N-isobutyrylguanine

: 81279-39-2
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: With (2R,4S)-3-((R)-cyclopentyl(1-methyl-1H-imidazol-2-yl)methyl)-4-isopropyl-2-methoxyoxazolidine; N,N-diisopropylethylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol402023c