tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate

Base Information

• Chemical Name: tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate
• CAS No.: 1372716-04-5
• Molecular Formula: C₂₂H₂₆NO₆P
• Molecular Weight: 431.425
• Mol file: 1372716-04-5.mol

Synonyms:tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate

Chemical Property of tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate

There total 1 articles about tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-oxopiperidine-1-carboxylic acid tert-butyl ester (85908-96-9) + chlorophosphoric acid diphenyl ester (2524-64-3) → tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate (1372716-04-5)

Guidance literature:

2-oxopiperidine-1-carboxylic acid tert-butyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - -70 ℃;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; toluene; at 0 ℃; Cooling;

DOI:10.1002/ejoc.201402258

Reference yield: 82.0%

tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate (1372716-04-5) + phenylacetylene (536-74-3) → 6-phenylethynyl-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In chloroform; at 55 ℃;

DOI:10.1021/jo4019914

Reference yield: 79.0%

tert-butyl 6-[(diphenoxyphosphoryl)oxy]-3,4-dihydropyridine-1(2H)-carboxylate (1372716-04-5) + 1-(but-3-yn-1-yl)-4-methoxybenzene (73780-78-6) → 6-[4-(4-methoxyphenyl)but-1-ynyl]-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In chloroform; at 55 ℃;

DOI:10.1021/jo4019914

upstream raw materials:

2-oxopiperidine-1-carboxylic acid tert-butyl ester

chlorophosphoric acid diphenyl ester

Downstream raw materials:

tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate

6-((2S,5S)-1-oxo-2,5-diphenyl-λ5-phospholan-1-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

tert-butyl 2-phenylipiperidine-1-carboxylate

6-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester