6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione
CAS No.:1281859-69-5
Molecular Formula:C₂₃H₂₅FN₂O₄
Molecular Weight:412.461
Hs Code.:

Synonyms:6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

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Chemical Property of 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

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Technology Process of 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

There total 5 articles about 6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1254831-82-7
6-benzyl-1-((4-fluorobenzyloxy)methyl)-3-hydroxy-5-isopropylpyrimidine-2,4(1H,3H)-dione

: 74-88-4
methyl iodide

: 1281859-69-5
6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

Guidance literature:: With caesium carbonate; In tetrahydrofuran; at 40 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm1014378

Reference yield:

: 1254831-91-8
6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione

: 1281859-69-5
6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: caesium carbonate / tetrahydrofuran / 3 h / 40 °C / Inert atmosphere

With sodium hydride; caesium carbonate; In tetrahydrofuran;
DOI:10.1021/jm1014378

Reference yield:

: 459-56-3
4-fluorobenzylic alcohol

: 1281859-69-5
6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro-trimethyl-silane / 20 °C / Inert atmosphere

2.1: N,O-bis-(trimethylsilyl)-acetamide; tetra-(n-butyl)ammonium iodide / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran / 3 h / 40 °C / Inert atmosphere

With chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm1014378