(1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

Base Information

Chemical Name:(1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate
CAS No.:1567324-86-0
Molecular Formula:C₂₀H₁₂ClF₃N₄O₂
Molecular Weight:432.789
Hs Code.:

Synonyms:(1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

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Chemical Property of (1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

Chemical Property:

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Technology Process of (1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

There total 3 articles about (1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888328-45-8
prop-2-ynyl 4-(trifluoromethyl)benzoate

: 69063-03-2
4-azido-7-chloro-quinoline

: 1567324-86-0
(1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; sodium L-ascorbate; In dichloromethane; water; at 20 ℃;
DOI:10.1016/j.ejmech.2013.11.022

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1567324-86-0
(1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 8 h / 20 - 85 °C / Molecular sieve

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate; sodium hydrogencarbonate / dichloromethane; water / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; sodium L-ascorbate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.11.022

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1567324-86-0
(1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methyl-4-(trifluoromethyl) benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate; sodium hydrogencarbonate / dichloromethane; water / 20 °C

With copper(ll) sulfate pentahydrate; sodium hydrogencarbonate; sodium L-ascorbate; triethylamine; In dichloromethane; water;
DOI:10.1016/j.ejmech.2013.11.022