bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
• CAS No.: 885702-45-4
• Molecular Formula: C₁₈H₁₈BrN₅O₃
• Molecular Weight: 432.277

Synonyms:bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

Chemical Property of bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

There total 2 articles about bromo-N⁴-(pyridin-2-yl)-N²-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(5-bromo-2-chloro-pyrimidin-4-yl)-pyridin-2-yl-amine (280582-65-2) + 3,4,5-Trimethoxyaniline (24313-88-0) → bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine (885702-45-4)

Guidance literature:

In butan-1-ol; for 16h; Heating;

DOI:10.1016/j.bmcl.2006.01.053

Reference yield:

2-aminopyridine (504-29-0) → bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine (885702-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / DIEPA / methanol / 16 h / 100 °C

2: 85 percent / butan-1-ol / 16 h / Heating

With N-ethyl-N,N-diisopropylamine; In methanol; butan-1-ol;

DOI:10.1016/j.bmcl.2006.01.053

Reference yield: 81.0%

(E)-2-Methoxy-3-tributylstannanyl-acrylic acid methyl ester + bromo-N4-(pyridin-2-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine (885702-45-4) → (Z)-2-Methoxy-3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-acrylic acid methyl ester (888969-39-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 4h; Heating;

DOI:10.1016/j.bmcl.2006.02.032

upstream raw materials:

(5-bromo-2-chloro-pyrimidin-4-yl)-pyridin-2-yl-amine

3,4,5-Trimethoxyaniline

2-aminopyridine

Downstream raw materials:

(Z)-2-Methoxy-3-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-acrylic acid methyl ester

[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-acetic acid ethyl ester

(E)-3-[4-(Pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-acrylic acid ethyl ester

2-[4-(pyridin-2-ylamino)-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-5-yl]-ethanol

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