1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Base Information

Chemical Name:1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
CAS No.:1442472-73-2
Molecular Formula:C₂₈H₂₇ClFN₅O₃
Molecular Weight:536.005
Hs Code.:

Synonyms:1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Suppliers and Price of 1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

There total 12 articles about 1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1442470-62-3
3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

: 103-71-9
phenyl isocyanate

: 1442472-73-2
1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1012878-91-9
3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442472-73-2
1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 6 h / 180 °C / Microwave irradiation

1.2: 3 h / 180 °C / Microwave irradiation

2.1: triethylamine / tetrahydrofuran / 20 °C

With triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442472-73-2
1-(4-chloro-5-(1-ethyl-2-oxo-7-(tetrahydro-2H-pyran-4-ylamino)-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

4.1: triethylamine / 1-methyl-pyrrolidin-2-one / 6 h / 180 °C / Microwave irradiation

4.2: 3 h / 180 °C / Microwave irradiation

5.1: triethylamine / tetrahydrofuran / 20 °C

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; water;