3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

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Chemical Name:3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one
CAS No.:1442470-62-3
Molecular Formula:C₂₁H₂₂ClFN₄O₂
Molecular Weight:416.883
Hs Code.:

Synonyms:3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

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Chemical Property of 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

There total 11 articles about 3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 38041-19-9
4-aminotetrahydropyran

: 1012878-91-9
3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442470-62-3
3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

Guidance literature:: 3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 6h; Microwave irradiation;

4-aminotetrahydropyran; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 3h; Microwave irradiation;

Reference yield:

: 959162-97-1
6-chloro-4-ethylamino-nicotinic acid ethyl ester

: 1442470-62-3
3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / water; tetrahydrofuran / 1 h / -50 - 0 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

4.1: triethylamine / 1-methyl-pyrrolidin-2-one / 6 h / 180 °C / Microwave irradiation

4.2: 3 h / 180 °C / Microwave irradiation

With manganese(IV) oxide; aluminum oxide; potassium fluoride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 959162-99-3
(6-chloro-4-(ethylamino)pyridin-3-yl)methanol

: 1442470-62-3
3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(tetrahydro-2H-pyran-4-ylamino)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 0.17 h / 20 °C

3.1: triethylamine / 1-methyl-pyrrolidin-2-one / 6 h / 180 °C / Microwave irradiation

3.2: 3 h / 180 °C / Microwave irradiation

With manganese(IV) oxide; aluminum oxide; potassium fluoride; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl acetamide;