21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid

Base Information

• Chemical Name: 21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid
• CAS No.: 1352814-10-8
• Molecular Formula: C₂₅H₄₅N₃O₁₀S
• Molecular Weight: 579.712
• Hs Code.: 2918999090
• Mol file: 1352814-10-8.mol

Synonyms:C₂₅H₄₅N₃O₁₀S

Chemical Property of 21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid

Chemical Property:

• Boiling Point: 818.4±65.0 °C(Predicted)
• PKA: 4.28±0.10(Predicted)
• Density: 1.196±0.06 g/cm3(Predicted)
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Biotin-PEG6-acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Biotin-PEG6-acid is a biotin PEG reagent. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule.

Technology Process of 21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid

There total 6 articles about 21-[D(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C29H53N3O10S (1352814-07-3) → C25H45N3O10S (1352814-10-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja2083015

Reference yield:

tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate (1286281-32-0,872340-65-3) → C25H45N3O10S (1352814-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja2083015

Reference yield:

C20H40O11S → C25H45N3O10S (1352814-10-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

2: hydrogen; acetyl chloride / methanol / 2 h

3: pyridine; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; sodium azide; hydrogen; triethylamine; acetyl chloride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja2083015

upstream raw materials:

tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate

tert-butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate

tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate

C₂₉H₅₃N₃O₁₀S

Downstream raw materials:

C₃₁H₄₄F₅N₃O₁₀S